Objective:To explore the effect of immue-enhancing enteral nutrients together with enteral microeco-pharmaceutics nutrition in patients undergoing radical gastrectomy surgery. Methods:Sixty gastric cancer patients were randomly divided into EN group(n = 15), EMN group(n = 15), EIN group(n = 15), and EMIN group(n = 15). Nitrogen balance, nutritional status, immune function, exhaust time and intestinal flora status were compared among the 4 groups. Results:The level of IgG, IgA and the quantity of Bacillus bifidus and Bacterium lacticum in intestinal canal is much higher in EIN group compare with those in EN group(P < 0.05). The level of the quantity of Bacillus coli and coccobacillus is much lower in EIN group compare with that in EN group in patients undergoing radical gastrectomy surgery(P < 0.05). The level of IgG, IgA and the quantity of Bacillus bifidus and Bacterium lacticum in intestinal canal is much higer in EMN group compare with that in EN group(P < 0.05). The level of the quantity of Bacillus coli and coccobacillus is much lower in EMN group compare with that in EN group in patients undergoing radical gastrectomy surgery(P < 0.05). The level of total protein, albumin, prealbumin, IgG, IgA, IgM, CD3, CD4, CD4/CD8, the nitrogen balance index and the quantity of Bacillus coli and coccobacillus in intestinal cana is muche higer in EMIN group compare with those in EN group(P < 0.05). The level of the quantity of Bacillus bifidus and Bacterium lacticum in intestinal canal is much lower in EMIN group compare with that in EN group in patients undergoing radical gastrectomy surgery(P < 0.05). The level of total protein, albumin, prealbumin, IgG, IgA, IgM, CD3, CD4 and CD4/CD8, nitrogen balance index, the quantity of Bacillus bifidus and Bacterium lacticum in intestinal canal in EMIN group, is much higher than than that in EMN and EIN groups while the quantity of Bacillus coli and coccobacillus in EMIN group is much lower than that in EMN and EIN groups in patients undergoing radical gastrectomy surgery(P < 0.05). The level of total protein, albumin, prealbumin, IgM, CD3, CD4, CD4/CD8, negative nitrogen balance index in EN group, EIN group and the group EMN three groups was no significant difference in patients undergoing radical gastrectomy surgery(P > 0.05). Conclusion:Supported by the combination of enteral microecopharmaceutics nutrition and immue-enhancing enteral nutrients in patients undergoing radical gastrectomy surgery, the level of metabolic and immunologic status is much higer, compared with the use of a separate intestinal immune eco-nutrition or microecopharmaceutics nutrition.