Objective:To investigate the left ventricular rotation and twist in patients with ventricular septal defect(VSD)after transcatheter closure of VSD. Methods:Using speckle tracking imaging(STI),the roation of 6 segments of basal and apical short-axises and LV twist were measured repeatedly in 18 patients with VSD before surgery,in 3rd day,1st month,3rd month after surgery.The global roation of the 6 segments in basal and apical short-axises and LV twist versus time profile were drawn,and the peak rotation of basal and apical short-axises and the peak twist of LV were caculated. LVEDd and LVEDV were caculated. LV ejection fraction(EF)was measured by biplane Simpson method. Results:Compared to before closure of VSD,the peak roation of basal and apical short-axises and peak twist of LV twist in 3rd day,1st month,3rd month after surgery were lower(P < 0.05),and the most was in 1st month after surgery. LVEDd and LVEDV were also lower in 3rd day,1st month,3rd month after surgery(P < 0.05),but the greater were in 3rd day after surgery .There were no significant differences between four groups in LVEF. The peak rotation of basal and apical short-axises and the peak twist of LV had a significant correlation with LVEF. Conclusion:After transcatheter closure of VSD,LV rotation,twist,LVEDd and LVEDV were decreased,and LV roation and twist had a significant correlation with LVEF,which may be a new index predicting LV systolic function.