Objective:To review the characteristics and spectrum of pathogen in patients with infection after total joint replacement and offer some data for antibiotics treatment. Methods:Some articles were selected from all the collected articles relevant to infection after total joint replacement from Chinese database since 2003 to 2008 and analyzed for their pathogen spectrum. Results: Forty-nine articles were selected for analysis, the main pathogens included gram-positive bacteria(which accounted for 80.49%), gram-negative bacteria(which accounted for 17.74%), mycobacterium(which accounted for 1.33%) and fungus(which accounted for 0.44%). In all pathogens, S.aurus accounted for 34.59% and S.epidermis accounted for 37.48%. Conclusion:Gram-positive bacteria are the main pathogen in patients with infected total joint replacement in China,most of which are S.aurus and S.epidermis. Selecting antibiotics properly are highly recommended.