Objective:To implement the standardized diagnosis and treatment of breast cancer,in order to enhance the medical quality,improve the quality of life,save medical cost and reduce medical expenses of patients with breast cancer. Methods:The study chose home medical records,clinical diagnosis and treatment information and detailed expense data of 1 164 cases of breast cancer in-patient in Jiangsu Provincial Tumor Hospital from January 2003 to September 2007,and used the minimum cost to carry on retrospective statistical analysis. Results:The average days of hospitalization of breast cancer patients by non-standardized and standardized comprehensive diagnosis and treatment were 60.59 days and 39.84 days respectively,the average times of hospitalization were 3.77 and 2.52 respectively,the total hospitalization expenses per capita were 54 863.27 yuan and 33 426.71 yuan,and all differences were statistically significant. Conclusion:The expenses of comprehensive treatment of breast cancer were relatively higher. The days of hospitalization,the average number of hospitalization and the total hospitalization expenses were reduced and the clinical treatment effects were improved after implementation of the standardized diagnosis and treatment. The implementation of standardized diagnosis and treatment of breast cancer was more feasible in clinical economics than non-standardized method,and had a better promotional and application value.