Objective:To investigate the safty and feasibility of active-fixation lead in patients with right ventricular outflow tract septum(RVOTS)pacing. Methods:Eighty patients were divided into two groups randomly. One group underwent the right ventricular outflow tract septum(RVOTS)with the active-fixation lead. The other group underwent the right ventricular apex(RVA)pacing with the passive-fixation lead. The parameters in and after operation of two groups were recorded and compared accordingly. Results:Operations went smoothly without complications in two groups. The active-fixation lead group had one case of wire dislocation,while the passive-fixation lead group also had one. Terms of X ray exposure time in active group were significantly longer than those in passive group(19.8 ± 6.4 vs 10.3 ± 4.8,P < 0. 01). After implantation of active electrode,the pacing thresholds were higher than those underwent passive electrode(0.61 ± 0.23 vs 0.48 ± 0.17,P < 0. 05). However,there was no difference between the two groups in pacing thresholds at one and three month point during follow-up. Pacing impedance and R-wave sensing between two groups had no significance. Meanwhile,there was no difference in the QRS duration between two groups. Conclusion:It is safe and feasible to pace in RVOTS with active electrode.