Objective:To investigate the significance of contrast-enhanced ultrasound in quantitative diagnosis of liver fibrosis and cirrhosis. Methods:Twenty cases of liver fibrosis and 20 cases of liver cirrhosis proven by biopsy were enrolled in this study while 10 cases without liver disease history served as controls. A real time gray-scale contrast enhanced ultrasound was performed with SonoVue bolus injection to determine hepatic artery to vein transit time (HA-VTT). Results:There is a significant difference of the HA-VTT among the three groups(P < 0.05). HA-VTT in hepatic cirrhosis group was shorter than controls(P < 0.01). Conclusion:Determination of HA-VTT were considered to be a new diagnostic method in quantitative diagonosis of hepatic fibrosis and cirrhosis.