objective:to study the correlation of mammographic signs to the expressions of er,pr(estrogen/progesterone recepter)and c－erbb－2 in infiltrating ductal carcinoma of breast(idc). Methods:pre－operative mammography was performed in all the 68 cases of patients with pathologically－proved idc of breast. The specimens of mastectomy of the idc were stained with immunohistochemistry,and the expression of er,pr,and c－erbb－2 were measured. Results:on the mammograms of the 68 cases,masses were shown in 54 cases(79.4%),spicule sign in 31 cases(45.6%),calcifications in 27 cases(39.4%)and breast architecture distortion only in 6 cases(8.8%). The positive expression of er,pr and c－erbb－2 were found in 41cases(60.3%),45 cases(66.2%)and 39 cases(57.4%)respectively. Er and pr positive expression was negatively correlated with the calcification of infiltrating duct carcinoma of breast(p﹤0.05),but c－erbb－2 positive expression was positively correlated with the calcification of infiltrating duct carcinoma of breast(p﹤0.05). Conclusion:the molybdenum target mammographic features of idc were closely correlated to the expressions of er,pr and c－erbb－2,and these features were in a considerable extent reflecting the biological behaviors of tumor cells and prognosis of cases. Therefore,molybdenum target mammographic features were helpful in treatment planning of breast cancer.