objective:to know the anemia status of patients with cleft lip and palate,further analyze certain specific related factors with their anemia prevalence,as well as furnish evidence for prevention to anemia. Methods:346 patients with cleft lip and palate who had received operation in stomatology hospital affiliated to njmu from january 2007 to november 2008,were analyzed statistically. The changes of rbc and hgb between before restoration and after restoration of 12 patients whose operations were all conducted in this hospital were also investigated. Results:according to the deformity type and restoration level,346 patients with cleft lip and palate are divided into 4 groups:cleft lip and palate group (a),cleft lip group (b),cleft palate group (c) and after restoration group (d). The anemia prevalence rates of these groups are 43.6%,40.5%,19.7% and 17.0%,respectively. The anemia prevalence rates of group a and group b are all higher than that of group d,and the anemia prevalence rates of group c and group d have no difference statistically. After standardization of urban－rural and gender composition,the anemia prevalence rates of group a,group b and group c,are all higher than that of chinese population in a same age group. The anemia prevalence rate of patients whose cleft lip and palate have not been restored completely did not obviously depend on the urban－rural and gender differences. In all the patients with cleft lip and palate,there were 81 anemia patients. In the 81 anemia patients,there were 44 microcytic hypochromic anemia patients. In 12 patients,the values of hgb increased significantly and the average values of rbc were in normal range when they were restored completely. Conclusion:the cleft lip and palate enhance the possibility of anemia,and the main type of anemia is microcytic hypochromic anemia. Scientific feed fashion should be widely published in the family of the patients with cleft lip and palate,especially when the patients are young,and let them pay attention to iron－content food intake.