objective:to study the effects of different anesthetic techniques on neonate perioperative stress response in the radical operation of hirschsprung’s disease. Methods:forty asaⅠ~Ⅱ neonate patients were randomly assigned into ga group and cb group with 20 each. Anesthesia in ga group was induced with fentanyl,midazolam,rocuronium and maintained with sevoflurane inhalation. Caudual block was performed in cb group after induction. Blood samples were taken before induction of anesthesia (t1),at beginning of operation (t2),30 min after incision(t3),30 min after operation(t4) and 24 hours after operation(t5). Serum levels of cortisol and interleukin－6(il－6) were measured. Systolic blood pressure(sbp),diastolic blood pressure(dbp) and heart rate(hr) were recorded at the same time. Results:in ga group,hr,sbp and dbp were significantly higher at t4 than those at t1 (p < 0.05). Hr,sbp and dbp were significantly higher at t4 in ga group than those in cb group(p < 0.05).compared with those at t1,the concentrations of cortisol at t4,5 were significantly higher in ga group(p < 0.05). The concentrations of cortisol at t4,5 in ga group were significantly higher than those in cb group(p < 0.05). Compared with those at t1,the concentrations of il－6 at t3-5 were significantly higher in both groups(p < 0.05). The concentrations of il－6 at t4,5 in ga group were significantly higher than those in cb group(p < 0.05). Conclusion:severe perioperative stress response may occur in neonate. General anesthesia combined with caudual block is superior to general anesthesia in alleviating the neonate perioperative stress response.