Objective:To evaluate the application value of ultrasound-guided thrombin injection (UGTI) against simple compression repair in the treatment of small interventional femoral pseudoaneurysms(PSA). Methods:Thirty patients with small interventional femoral arterial pseudoaneurysms firstly received simple compression repair. The pressure should not beyond the endurability of the patients and the throbbing of the feet arterial should be palpable. With 48 hours of compression,12 patients have been cured with satisfactory outcomes. The rest eighteen patients,who can not endure the therapy or who haven’t been successfully cured,received percutaneous puncture with 20 G needle under ultrasound guidance,and were treated by intracavitary thrombin injection. The concentration of thrombin injection was 200 U/ml,the total volume dose was no more than 500 U. Results:Twelve patients were successfully cured at the first time by simple compression repair. No recurrence and complication were found in a three-month followup. The other eighteen patients,who can not endure the therapy or who haven’t been successfully cured by this therapy,were successfully treated afterwards by ultrasound-guided thrombin injection (UGTI). No complication occurred during the operations or after the operations. and no recurrence and complication were found in a three-month followup. Conclusion:During the treatment of interventional femoral pseudoaneurysms (PSA),simple compression repair is first recommended if the body of PSA is small,and the neck is narrow. Otherwise it should be treated by thrombin injection under sonographic guidance for better outcomes.