Objective:To exaluate the value of clinical application of microinvasive approach to sellae region. Methods:Using neuro-endoscope and microscope,56 sellar region tumor cases accepted microinvasive operation. 43 cases were given keyhole approach,13 cases accepted endonasal transsphenoidal approach operation. Results:Total tumor resection was achieved in 21 cases,subtotal in 4,and partial in 1 case. The visual acuity were ameliorated in 11/13 cases,and the high level of hormones was decreased to normal degree in 15/20 cases. No case was found recurrence by MRI during 2 years follow-up. According to Hunt-Hess grade:4 cases ofⅠ grade and 8 cased of Ⅱgrade were cured by clipped the aneurysm,and cerebral angio spasm was found in one case of 3 of Ⅲ grade,and other two cases gained satisfied result. 8 case of meningeomas gained SimpsomⅡ resection,the visual acuity was ameliorated and no complications were found. Conclusion:It is available to decrease the morbility and improve the removal rate by corresponding mininvasive approaches according to different location of lesions.