Objective:To investigate the variety of resistin,CRP,TNF-α and IL-1β in the rat of acute pancreatitis. Methods:Forty Sprague-Dawley rats were randomly divided into four groups:control group,sham operation group,AEP group and ANP group. AEP model was induced by intraperitoneal injection of cerulein,and ANP model was established by intraperitoneal injection of L-arginine while the control group didn’t receive any interference and the sham opertation group received same volume injections of 0.9% saline solution. The level of amylase,resistin,CRP,TNF-α and IL-1β were determined in blood serum by using ELISA,and pancreas/body weight ratio was evaluated and pancreatic pathology was recorded. The level of resistin was detected in pancreas by immunohistochemistry. Results:The levels of amylase,pancreas/body weight ratio,pancreatic pathology,resistin,TNF-α,IL-1β and CRP were respectively(4376.70±342.95)U/L,(8.67±1.43)g/kg,5.39±0.26,(10.21±3.34)ng/ml,(184.18±45.24)pg/ml,(194.24±44.81)pg/ml,(3585.85±157.28)ng/ml in AEP group;and were respectively (6750.2±321.81)U/L,(9.33±1.76)g/kg,7.81±0.28,(15.14±3.11)ng/ml,(349.31±94.54)pg/ml,(315.59±37.04)pg/ml,(4345.04±661.53)ng/ml in ANP group. All the indexes were significantly higher than those in the control group and the sham operation group(P < 0.01),the levels of the indexes in ANP group were higher than those in AEP group(P < 0.01 or P < 0.05). Resistin was correlated with the increase of CRP,TNF-α,IL-1β and the pathologic severitity of pancreatitis,respectively,(r=0.711,0.812,0.794,0.812,P < 0.01). The pathologic severitity of pancreatitis was correlated with the level of CRP,TNF-α,IL-1β. Conclusion:The resistin is correlated with the pathogenesis and development of acute pancreatitis,and may be useful to predict the severity and prognosis of acute pancreatitis.