Objective:To explore the effect of the GIK united torasemide on traumatic brain edema and recovery of neuronal function. Methods:Ninety patients with craniocerebral injury were randomly divided into control group,GIK group and group of GIK united torasemide according to different grades of Glasgow coma score. Each group had totally 30 patients including ten people with 3~8 score,10 with 9~11 score and 10 with 12~14 score. The head MRI was performed after 3 days and 14 days;the levels of the CRP,TNF-α,IL-6,white blood cell(WBC),neutrophil,SOD and MDA were measured on the 2 nd day and 14 th day;the EEG,Glasgow score was analyzed on the 14 th day. Results:The levels of the CRP,TNF-a,IL-6,WBC,neutrophil and MDA in the GIK group and the group of GIK united torasemide were significantly lower than those in the control group(P < 0.01),while the level of the SOD in the GIK group and the group of GIK united torasemide was significantly higher than that in the control group(P < 0.01),and the GIK group was not significantly different from the group of GIK united torasemide. The indexes mentioned above were not significantly different in every group on the second day. The levels of cerebral edema,the EEG,the Glasgow coma score in the group of GIK united torasemide were significantly better than others groups on the 14 th day. Conclusion:By reducing inflammatory cytokines and the excitability of the damaged neurons,anti-oxidation and dehydration,the treatment of GIK united torasemide can significantly reduce traumatic brain edema and promote recovery of neuronal function.