Objective:To investigate the safety and effectiveness of hydrodissection with diclofenac sodium and nuclear rotation on the prevention of posterior capsular opacity. Methods:179 patients(200 eyes)with age-related cataract were divided into four groups randomly and underwent phacoemulsification with IOL implantation. Hydrodissection was done with balanced salt solution,lidocaine,diclofenac sodium,diclofenac sodium and nuclear rotation in group A,B,C,and D respectively. Visual acuity,corneal endothelial cell density and grade of posterior capsular opacity(PCO) were measured. Results:There were no significant differences between four groups in the best corrected visual acuity and corneal endothelial cell density(P > 0.05). The PCO score of group C and D were lower than group A and B,and the PCO score of group D was lower than group C. Conclusion:Hydrodissection with diclofenac sodium and nuclear rotation is effective in preventing posterior capsular opacity and can be safely used in ophthalmic surgical practice.