Objective:To investigate the clinical effect on resection of stage Ⅲ and Ⅳ gastric cancer after neoadjuvant chemotherapy with the combination of docetaxel,oxaliplatin fluorouracil and leucovorin. Methods:From January,2005 to August,2008,40 patients with stage Ⅲ and Ⅳ gastric cancer received the neoadjuvant chemotherapy 4~6 weeks before operation. Neoadjuvant chemotherapy regimen consisted of 60 mg/m2 docetaxel(Day 1),75 mg/m2 oxaliplatin(Day 5),500 mg/m2 fluorouracil(Day 1 to 5)and 200 mg/m2 leucovorin(Day 1 to 5)administered every 4 weeks for 2~3 cycles before operation. Results:Objective response rates were 70%;Objective pathological response rates were 85%;Total resection rates were 85%;Curative resection rates were 62.5%;TTP was 6.4 months;MST was 20.6 months. Major side effects were myelosuppression,nausea and vomiting. No serious complications were observed. Conclusion:The overall curative resection rates and the compliance were increased in patients with the stage Ⅲ and Ⅳ gastric cancer after the neoadjuvant chemotherapy with the combination of docetaxel,oxaliplatin fluorouracil and leucovorin.