Objective:To compare the eradication rates of H.pylori among 7-day levofloxacin- based triple therapy,10-day levofloxacin-based sequential regimen and conventional sequential therapy. Methods:The total 64 patients with H.pylori were randomly divided into three groups. Eighteen patients in group A were treated with proton pump inhibitor(PPI),amoxincillin and levofloxacin for 7 days. Tweenty-five patients in group B were treated with PPI and amoxicillin for 5 days,and then with PPI,clarithromycin and tinidazole for another 5 days. Tweenty-one patients in group C were treated with PPI and amoxicillin for 5 days;and then with PPI,levofloxacin and tinidazole for another 5 days. Results:The eradication rate of 7-day levofloxacin-based triple therapy was 83.33%;the eradication rate of conventional sequential therapy was 84%;and that of 10-day levofloxacin-based sequential regimen was 76.19%. Conclusion:There were no significant difference in eradication rate of H.pylori among 7-day levofloxacin-based triple therapy,10-day levofloxacin-based sequential regimen and conventional sequential therapy.