Study of the association of NT-proBNP and TNF-α levels with the extent of coronary artery disease
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    Abstract:

    Objective: To study the association of N-terminal pro-brainnatriuretic peptide(NT-proBNP), tumor necrosis factor-α(TNF-α) levels and the extent of coronary artery disease(CAD). Methods:One hundred and twenty CAD patients and thirty-five non-CAD patients were included in this study. All of the subjects were verified with coronary angiography. In the light of the types of CAD, CAD patients were assigned into three groups (SAP group, UAP group, AMI group), the comparisons of NT-proBNP and TNF-α levels were performed among the SAP, UAP, AMI and non-CAD groups. According to the number of suffered coronary artery, CAD patients were divided into groups of single-vessel, double-vessel and three-vessel. The associations of the levels of NT-proBNP and TNF-α with CAD severity were also evaluated. Results:We found a significant association between the types of CAD and changes of NT-proBNP or TNF-α level. We also observed that change of TNF-α, not NT-proBNP, was significantly associated with the number of vessels of suffered coronary artery. Conclusion:NT-proBNP and TNF-α may be useful markers of the extent of CAD.

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徐崇利,严建军,张郁青,陈广胜,朱 军,王连生.氨基末端脑钠肽原及TNF-α与冠心病的相关性研究[J].南京医科大学学报(自然科学版英文版),2011,(1):61-64.

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  • Received:October 10,2010
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