Objective: To analyze the incidence rate and and management of adverse reaction in dual-source CT coronary arteriography(DSCT-CCTA). Methods: Total 1405 patients who received DSCT coronary angiography examination were enrolled in this study from Jan 1, 2010 to May 18, 2010. Considering both the allergic history and the pre-examination management, the incidence rate and the medical managements of adverse reaction were recorded and analyzed. Results: There were 79 patients who had a history of drug allergy or other allergic diseases. Adverse reaction occurred in 18 patients of those patients. The other 1 326 patients had no history of allergic disease, and adverse reaction occurred in 35 patients (P < 0.01). Among those patients of allergic history, 42 cases received pre-examination treatment of Dexamethasone. There was no significant difference of the incidence rate of adverse reaction between those patients with or without pre-examination treatment (P > 0.05). However, allergic shock occurred in two patients without pre-examination treatment of Dexamethasone. Those 53 patients with adverse reaction recovered after proper medical treatment. Conclusion:When adverse reaction occurs during the DSCT-CCTA, patients should be treated individually according to the degree of adverse reaction. Adverse reaction was highly correlated to allergic history. Pre-examination treatment of Dexamethasone could not reduce the incidence rate of adverse reaction significantly, but may relieve the degree of adverse reaction.