Objective:To investigate effects of budesonide on the expression of phosphorylated vascular endothelial growth factor receptor 2(VEGFR2) in asthmatic mice with airway remodeling. Methods:Twenty-four BALB/c mice were randomly divided into control group, asthma group and budesonide intervention group. The mice were sensitized and challenged with ovalbumin(OVA) to establish the chronic asthmatic model. Budesonide (10 ml) was atomized half an hour before sensitization in budesonide intervention group. After finished the last sensitization for 24h, the mice were sacrificed. Right lungs were isolated and stained with haematoxylin and eosin (HE). Immunohistochemistry was used to detect the expression of phosphorylated VEGFR2, and Western blot was applied to examine the expressions of phosphorylated VEGFR2 and Erk in the left lungs. Results:There were bronchial airway remodeling and mass inflammatory cells infiltration in asthmatic group; budesonide intervention ameliorated the symptoms mentioned above significantly. The protein expression levels of phosphorylated VEGFR2 and Erk in asthmatic group were higher than those of the control group(P < 0.01), and both of them decreased dramatically in the budesonide intevention group(P < 0.01). Conclusion:The expressions levels of phosphorylated VEGFR2 and Erk in asthmatic mice were much higher than control group, and budesonide could inhibit phosphorylation of them, thus relieve airway inflammation and delay the process of airway remodeling.