Objective:To investigate if the change of N-terminal Brain natriuretic peptide(NT-ProBNP) level with the effect of cardiac resynchronization therapy(CRT). Methods:A retrospective review on 33 patients with CRT/CRT-D during 2005-2009 was conducted. Patients have been followed up for at least 6 months. The patient whose left end-systolic volume decreased by 15% after implantation was considered as responder to CRT. Results:After the implantation, the level of NT-ProBNP decreased significantly in the respond[(2.90±0.57)ng/L vs (3.38±0.47)ng/L,P=0.001], which was in linear regression relationship with the variation of left ventricular end-diastolic volume(b=-0.499,R2=0.489,P=0.001). However, there was no such linear regression relationship existed in non-responder group. The reduction of NT-ProBNP level more than 13% predicted a responsive CRT(HR=14,P=0.02). Conclusion:The reduction of the plasma NT-ProBNP level more than 13% can predict CRT responsiveness. The change of plasma NT-ProBNP level is valuble to monitor of CRT effect.