Objective:To observe the changes of CD4+CD25+Foxp3+T cells in patients with multidrug-resistant tuberchlosis(TB). Methods:We recruited 31 multidrug-resistant TB(MDR-TB) patients,33 drug-susceptible TB(S-TB) patients and 30 healthy controls. Flow cytometry was used to determined the quantity of CD4+CD25+Foxp3+T cells in the peripheral blood. Results:The mumber of CD4+CD25+Foxp3+T cell in the peripheral blood of patients with S-TB was(2.43±0.69)% of peripheral CD4+ T cell, it was significantly higher than heathy controls [(1.61±0.46)%]and lower than patients with MDR-TB[(3.14±0.59)%]. Conclusion:CD4+CD25+Foxp3+T cells increased in MDR-TB patients significantly, this suggests that CD4+CD25+Fox3+ T cells play an important role in the pathogenesis of MDR-TB.