objective:to evaluate the expression level and clinical significance of adiponectin gene on abdomen adipocyte in the patients with gastrointestinal cancer. methods:the study included the samples from surgical patients who were mainly divided into two groups, the cancer group(n=39) and the control group(n=20). then the gastrointestinal cancer group contained the metastasic group (n=21) and the no-metastasic group(n=18). total rna were collected from adipocyte, and the expression level of adiponectin have been detected with real-time pcr. results:the expression level of adiponectin mrna in cancer group was significantly lower than control group(p < 0.05), and the expression level in the metastasic group(3.85±1.41) was lower than the no-metastasic group(4.90±1.06), but there was no significance(p > 0.05). conclusion:the expression level of abdomen adipocyte adiponectin gene may be involved in the gastrointestinal tumor generation, which can provide theoretical foundation for a new treatment.