objective:to investigate the susceptibity of c-reaction protein(crp) gene c+1444t polymorphisms to acute coronary syndrome (acs). methods:from nov 2003 to may 2008, 443 inpatients with acs (acs group) were recruited, the control group was consisted of 285 subjects who were free of coronary artery disease confirmed by coronary angiography. the crp gene c+1444t polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphisms analysis. results:there were no significant differences in the frequencies of cc, ct and tt genotype between acs group and control group (83.7% vs 86.7%, 14.4% vs 12.3% and 1.8% vs 1.1%,p were 0.292, 0.439 and 0.540, respectively). the prevalence of c allele were 91.0% and 92.8% for acs group and control group, respectively(p=0.243). furthermore, after adjusted for multiple factors such as age, sex, smoking, systolic pressure, diastolic pressure, blood glucose, and blood lipids, the multivariate logistic regression analysis indicated that there was no significant correlation between the crp gene c+1444t polymorphisms and acs(p > 0.05). conclusion:the present findings suggest that the crp gene c+1444t polymorphisms may be no related to acs susceptibility in the chinese han population of suwan region.