Objective:To assess the association of monocyte chemotactic protein-1(MCP-1)gene G2518A and CC chemokine receptor 2(CCR2) gene G190A polymorphisms with coronary artery disease(CAD). Methods:Databases, including PubMed, EMbase, CNKI and CBM, were searched to get the association studies on MCP-1/CCR2,RANTES/CCR5 genes polymorphisms and CAD. Results:A total of 21 case-control studies were identified. The Meta-analysis included 6 835(MCP-1-G2518A) CAD case and 11 142 controls,2 801 CAD cases and 5 789 controls(CCR2-G190A),respectively. MCP-1 gene G2518A polymorphism was significantly associated with CAD(P = 0.04). The CCR2 gene G190A polymorphism was also significantly associated with the presence of CAD(P = 0.005). In stratified analysis by race, the MCP-1 gene G2518A polymorphism was significantly associated with the presence of CAD in non-Asian(P = 0.04), while not in Asian(P > 0.05). Conclusion:Our results showed that the MCP-1 gene G2518A and CCR2 gene G190A polymorphisms were associated with an increased risk of CAD.