Objective:To evaluate the therapy effects of glargine on glucolipid metabolism and B-cell function,insulin detection in newly diagnosed type 2 diabetes mellitus(T2DM) patients. Methods:Thirty-two cases of newly diagonosed T2DM,were treated with subcutaneous injection of glargine at fixed time everyday. Fasting serum glucose,blood lipid,blood pressure,the HOMA-IR were detected and compared after three months treatment. Results:After three months treatment,blood lipid,blood pressure,blood glucose,glycohemoglobin A1c(HbA1c) were significantly lower,the bodyweight had no signifancanct difference compare with the un-treatment group;the level of the HOMA-B were significantly higher after treatment;the HOMA-IR were significantly lower(P < 0.01). Conclusion: Glargine can effectively improve,control serum glucose,blood lipid,blood pressure,and the glaginetreatment did not influence the detection of insulin.