Objective:To explore the prognosis of VEGFR-2 expression and its correlation with the clinical pathological characteristics in the parenchyma of NSCLC. Methods:The tissue microarray (TMA) technique and immunohistochemistry stain were used to detect the expression of VEGFR-2 protein in 217 non-small cell lung cancer tissues. Results:The positive expression rate of VEGFR-2 in parenchyma of NSCLC is 63.1%. And the gene expression was significantly correlated with tumor differentiation,TNM stage,lymph node metastasis and perineural invasion(P < 0.05). Moreover,the median survival for patients with the positive expression of VEGFR-2 was longer by 12 months than that for patients with negative expression(P < 0.049). Conclusion:VEGFR-2 plays an important role in the genesis,devedopment and prognosis of non-small cell lung cancer.