Objective: To explore the potential value of serum uric acid (SUA) level as a marker of metabolic syndrome (MetS) in middle-aged and elderly Chinese. Methods: A cross-sectional study was conducted to investigate 1 136 agency staff aged 40 to 92. Blood samples were collected for the determination of blood glucose,lipid profile and SUA. The relationship between MetS and SUA was analyzed. Results: The more components of MetS,the higher SUA levels. The prevalence of MetS elevated with the increasing SUA. SUA concentration was positively correlated with waist circumference(WC),waist-to-hip ratio(WHR),waist-to-hight ratio(WHtR),body mass index(BMI),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C) and systolic blood pressure(SBP),and negatively correlated with hight density lipoprotein-cholesterol(HDL-C). Multiple variants Logistic regression analysis showed that abnormal hypertension,central obese and high TG were main factors to hyperuricemia(HUA),female was the protective factor. Conclusion: HUA is common in middle-aged and elderly Chinese,increased SUA level significantly correlates with metabolic disorders. HUA was intimately related to MetS components and might be an important factor of MetS. SUA is more closely associated with MetS in females than in males.