Objective: To investigate the correlative factors of hyperuricemia and metabolic syndrome (MS) and study the role of uric acid (UA) in the development of MS. Methods: Data of 12 249 persons undergoing health examination were collected. The disease history was investigated,the biochemical indices were detected,and the general physical data were measured. Multiple stepwise by multivariate Logistic regression model were used to analysis the relationship between UA and MS,at the same time,age,sex,low density lipoprotein cholesterol,total cholesterol were adjusted,the relationship of UA and other factors related to metabolism was also analyzed. Results: Age,BMI,blood pressure,lipids,glucose and UA were higher in MS group than those in non MS group(P < 0.01). The UA level was higher in men than that in women,and increased with accompany the costitution of MS. This phenomenon was obviously in woman. The UA level was increased in man under different glucose levels. Similarly,the UA level was related to the abnormal lipid metabolism,but not related to ages. After adjusting age,sex,total cholesterol,low density lipoprotein cholesterol,the rate of MS were higher in the hyperuricemia group when the UA was analyzed as continuous variable,but when uricemia was divided into two groups,the rate of MS in hyperuricemia group was 1.197 times of that in no hyperuricemia group,but non significant difference was found between them. When uricemia was divided into four groups,there were no differences among them. Conclusion: Age,BMI,lipids,glucose,uricemia were the risk factors of MS,hyperuricemia was found in MS group,and hyperuricemia group has higher rate of MS than the non hyperuricemia group,but no direct relationship between MS and hyperurcemia was found when the uricemia was divided into two groups or four groups