Objective: To investigate the potential relationship between amnestic mild cognitive impairment (aMCI) and metabolic disorders(MD). Methods: Totally,136 persons were included and divided into aMCI group(male/female=44/49,average age=73.01 ± 7.12 years) and control group (male/female=25/18,average age=73.77 ± 7.37 years). The histories of MD were all recorded. Fasting blood glucose(FBG) and glycated hemoglobin(HbA1c) were detected by dry chemistry method. Interleukin 6(IL-6) was detected by enzyme-linked immunosorbent assay. Results: IL-6 was highly expressed in the aMCI group[(78.57 ± 2.37) pg/ml],compared with control group[(72.48 ± 4.74)pg/ml,P < 0.05]. There was no significant difference between the two groups in FBG and HbA1c (P > 0.05). Furthermore,the diabetes and hypertension were proved as the common risk factors(P < 0.05). Interestingly,smoking is a risk factor only in male aMCI patients. Conclusion: The present study demonstrated that the history of diabetes,hypertension and male smoking placed an important part in the generation of aMCI. The reason might partly be ascribed to the inflammation state caused by the risk factors.