Objective: To investigate the clinical efficacy of neoadjuvant chemotherapy used for locally advanced cervical cancer patients. Methods: Total 52 cases of Ⅰb2~ Ⅱb cervical cancer were included. According to pathological types of the cancer cells,2 to 3 cycles of combined chemotherapy were used before surgery,then extensive hysterectomy and pelvic lymph node dissection would be done. Results: After preoperative chemotherapy,symptoms and signs of all patients were significantly improved,it created favorable conditions for the radical surgery,total clinical effective rate was 92.5%,and surgery rate was 88.50%(46/52). Conclusion: The use of neoadjuvant chemotherapy for the locally advanced cervical cancer before surgery can alleviate clinical symptoms significantly,reduce size as well as the invaded area of the tumor,lower clinical stage and improve the surgery rate,reduce risk factors and the relapse rate,and it can be expected to extend 5-year survival.