Objective: To study the immediate protective effect of intensive atorvastatin treatment on coronary artery disease (CAD) patients in the perioperative period of percutaneous coronary intervention (PCI). Methods: Sixty CAD patients were randomly divided into two groups. The levels of creating kinase MB(CK-MB),cTroponin T (cTnT) were measured before and 24 h after PCI. Results: The frequencies of CK-MB > 3 UNL(14.3% vs 9.4%) and CK-MB > 1 UNL(21.4% vs 9.4%) was insignificant in the conventional treatment and intensive atorvastatin treatment groups at 24 h after PCI(CK-MB > 3 UNL,OR:0.62,95%CI:0.13~3.05,P = 0.695;CK-MB > 1 UNL,OR:0.38,95%CI:0.09-1.69,P = 0.281). In the two groups,the occurrences of cTnT > 3 UNL(7.1% vs 6.3%) and cTnT > 1 UNL (14.3% vs 12.5%) were not remarkable at 24 h after PCI(cTnT > 3 UNL,OR:0.62,95%CI:0.13~3.05,P = 0.695;cTnT > 1 UNL,OR:0.86,95%CI:0.19~3.80,P = 1.000). Conclusion: For the CAD patients,the enhanced atorvastatins in the perioperative period of PCI would not further reduce the rates of myocardial necrosis and infarction.