Objective: To explore the application of ARIMA model on prediction of hepatitis E in Jiangsu Province. Methods: Eviews 5.0 software was performed to construct the ARIMA mode based on monthly incidence of hepatitis E from 1997 Jan to 2009 Dec in Jiangsu province,and the constructed model was applied to predict the monthly incidence in 2010. Results: ARIMA(3,1,1)(1,1,0)12 exactly fitted the incidence of the previous time series,and got a good result on the predictive incidence in 2010. Conclusion: The ARIMA model can be used to make a short-term prediction and a dynamic analysis on hepatitis E.