Objective: To analyze and compare the epidemiological characteristics of the patients who received highly active antiretroviral therapy(HAART) during 2005 to 2010 in Jiangsu province. Methods: According to the base data of patients during 2005 to 2010,Excel database was established and statistical analysis was performed using SPSS 17.0 software. Results: There were 1 276 patients during 2005 to 2010 totally,the number of patients were increasing by the year. There was 93.7% of the patients from Jiangsu province;the ratio of male to female was 2.7∶1;the average age was 39.2 years old and the number of young patients aged 16 to 25 was increasing;65.1% of the patients have married;patients were mainly detected and diagnosed by hospitals;76.1% of the patients were infected with HIV through sexual transmission,while the proportion of men who have sex with men(MSM) is significantly higher in 2010 than before;the average CD4+ T cell counts of cases were only 134.9 counts/μl;147 days as the median of the interval between the time of HIV confirmation and anti-retroviral therapy(ART) beginning,both of them are significantly different from those during 2005 to 2009. Conclusion: It’s late for the AIDS to start HAART in Jiangsu province during 2005 to 2010,although it’s earlier than before. In view of the AIDS patients were diagnosed at late stage,earlier detection and diagnosis of HIV positive cases still should be strengthened.