Abstract:Objective:To investigate the association of a single nucleotide polymorphism(SNP),rs7574865 G>T,of the signal transducer and activator of transcription 4 (STAT4) with Crohn’s disease(CD) in the Chinese Han population. Methods: Genomic DNA from 636 individuals of Chinese Han origin including 318 patients with CD and 318 healthy controls was analyzed for the SNP (rs7574865) of the STAT4 gene. SNP rs7574865 G>T was genotyped by polymerase chain reaction and direct sequencing. A Chi-square test was used to determine the association of SNP with CD. Results: The frequencies of genotypes GG,TG and TT at SNP rs7574865 G>T were 0.110,0.431 and 0.459 in CD patients,while 0.097,0.450 and 0.453 in healthy controls. The frequency of G or T allele was 0.325 or 0.675,respectively in CD patients,while 0.322 or 0.678 in healthy controls. Conclusion: These findings indicate that no significant difference is observed between STAT4 polymorphism and Crohn’s disease in the Chinese Han population.