Objective:To investigate the efficacy and safety of magnetic navigation system in patients with non-ST-elevation acute coronary syndromes(NSTE-ACS). Methods: Total 37 consecutive patients with NSTE-ACS were assigned to undergo magnetic guide-wire navigation PCI(MPCI). Time to cross lesion,fluoroscopy time,contrast usage to cross lesion and procedure-related complication were recorded and analyzed. Results: Of the 37 culprit lesions in MPCI,36 were crossed successfully giving a success rate of 97.3%. The average stenosis of the target lesions was(88.07 ± 8.33)%,mean length was(27.08 ± 8.98) mm. The procedure and the fluoroscopy time to cross the lesion in the magnetic PCI were (82.0 ± 67.9) s and(62.6 ± 57.6) s,respectively. The contrast medium used to cross lesion were(6.3 ± 4.6) ml. The failed lesion was a subtotal stenosis combined with severe calcification. No magnetic navigation system associated complications or major adverse cardiac events were observed in MPCI. Conclusion: It is feasible and safe to use the magnetic navigation system as a tool for treatment in patients with NSTE-ACS.