Objective: To study the tissue distribution of docetaxel liposomes modified with galactose ligand (Gal-DOC-L) in mice after intravenous injection,and to discuss the liver targeted effects of Gal-DOC-L. Methods: The determination of drug tissue distribution in mice was measured by HPLC,relative uptake rate (re),peak concentration ratio (Ce) and targeting efficiency (te) were used as the evaluation parameters to evaluate the DOC-L,Gal-DOC-L’s liver targeted effect. Results: The relative uptake rates of DOC-L and Gal-DOC-L were 2.80 and 4.34,peak concentration ratios of DOC-L and Gal-DOC-L were 1.67 and 2.38,targeting efficiency percentages of DOC-L and Gal-DOC-L were 28.44% and 38.91%. Conclusion: The drug encapsulated by liposomes has a certain effect of targetability,and liposomes modified with galactose ligand-targeted could further improve the hepatic targeted effect.