Objective:To detect the change of plasma adiponectin and its correlation with inflammatory cytokines after hypertensive cerebral hemorrhage. Methods: Blood samples of 30 cases in control group and 43 patients with hypertensive cerebral hemorrhage were obtained 1,2,3,5,and 7 days after hospitalization. Enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay were used to measured concentrations of plasma adiponectin,interleukin-6 (IL-6),C-reactive protein (CRP) and tumor necrosis factor-α(TNF-α). Results: After hypertensive cerebral hemorrhage,the level of plasma adiponectin increased immediately within 6 h,reached the peak at 24 h,and decreased gradually after 2 days. The adiponectin concentration was higher in patients with hypertensive cerebral hemorrhage than control group during 7 days. The levels of plasma IL-6,CRP,and TNF-α in patients with hypertensive cerebral hemorrhage were significantly higher than those in control group,and were associated with adiponectin level. Conclusion: The change of plasma adiponectin was a dynamic process. Together with IL-6,CRP,and TNF-α,plasma adiponectin may be involved in the inflammatory responses injury after cerebral hemorrhage.