Objective:To investigate the relationship of transient receptor potential canonical channel 3 (TRPC3) transcription and mRNA levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in monocytes,and monocyte chemoattractant protein 1 (MCP-1) level in peripherial blood of patients with essential hypertension (EH). Methods: The levels of TRPC3,TNF-α and IL-1β mRNA in monocytes of 20 patients with essential hypertension and 20 normotensive controls were analyzed by real-time PCR,the concentration of MCP-1 was measured by enzyme linked immunosorbent assay (ELISA). Results: The elevated TRPC3,TNF-α,IL-1β mRNA levels in monocytes and MCP-1 protein in peripherial blood were observed in patients with essential hypertension. There were significant differences between the two groups(P < 0.05). The level of TRPC3 mRNA was positively correlated with the levels of TNF-α,IL-1β mRNA and MCP-1 protein. Conclusion: Essential hypertension is condsidered as a chronic inflammation process. The expression of TRPC3 in monocytes is related to cytokines. Overexpression of TRPC3 may be regarded as one of indicators of activations of monocytes.