Objective:To assess the differences in cardiopulmonary functions between laparoscopic and open surgery for colorectal carcinoma complicated with primary hypertension. Methods: The clinical data of 205 patients with colorectal carcinoma complicated with primary hypertension between May 2008 and July 2010 in the Second Affiliated Hospital of NJMU were prospectively analyzed. Of all the patients,200 cases were finally included in the study,and were randomly allocated to laparoscope group (n = 102) and conventional operation group(n = 98). The HR,SBP,DBP and the results of blood gas analysis of patients at 1st day before operation,interoperation,1st day after operation were recorded,pulmonary function on the 1st day before and after operation was analyzed as well. Results: The SBP,DBP and PaCO2 during interoperation increased significantly in the laparoscopic group than that in the conventional operation group. But on 1st day before operation and 1st day after operation,the results were not different between the two groups. Pulmonary function is better preserved after laparoscopic operation than that after conventional operation on the 1st day after operation. Conclusion: With equal degree of radical resection,laparoscopic technique for colorectal carcinoma complicated with primary hypertension causes less cardiopulmonary function injury as compared with conventional operation.