Objective:To discuss the characteristics of glucose and lipid metabolism and the relationship between plasma PCSK9 and relative metabolic factors in adolescents and young adults. Methods: Blood samples were obtained from 54(22 males and 32 females) subjects who were diagnosed as obese. Questionnaires,physical examinations,oral glucose tolerance test (OGTT),lipid profile,and other metabolic factors were performed on these objects. Serum PCSK9 was measured with Sandwich ELISA. Results: Data showed that the bone mass index(BMI) was positively correlated with fasting blood glucose(FBG),fasting insulin (FINS),fasting C peptide (FCP),HOMA insulin resistance index (HOMA-IR)(r = 0.386,0.488,0.363,0.546,P < 0.05). BMI was positively correlated with total triglyceride (TG),total cholesterol (TC),low density cholesterol (LDL-C)(r = 0.365,0.274,0.305,P < 0.05),and it was negatively correlate with high density cholesterol(HDL-C)(r = -0.270,P < 0.05). BMI was positively correlate with C-reactive protein (CRP)and gamma-glutamyl transferase (γ-GGT) (r = 0.577,0.417,P < 0.05 ). It was negatively with total bilirubin (TBIL)(r = -0.322,P < 0.05). PCSK9 was positively correlated with BMI,FINS,HOMA-IR(r = 0.406,0.535,0.496,P < 0.05). There was no significant correlation with BMI and blood lipid levels such as TG,TC,LDL-C,HDL-C(r = 0.089,0.237,0.269,-0.002,P > 0.05). CRP was positively correlated with FINS,FCP,HOMA-IR,TG(r = 0.331,0.464,0.494,0.530,P < 0.05). γGGT was positively correlated with FBG,TG (r = 0.284,0.501,P < 0.05). γGGT was negatively correlated with HDL-C(r = -0.289,P < 0.05). TBILI was negatively correlated with FINS,FCP,LDL-C(r = -0.324,-0.290,-0.315,P < 0.05). Conclusion: There were multiple abnormalities of glucose and lipid metabolism in obese adolescents and young adults in this study. PCSK9 was closely related to FINS and HOMA-IR. The prevention of obesity might help to prevent future cardiovascular disease and type 2 diabetes in adolescents and young adults.