Objective:To investigate the expression profile of Mcl-1 in cervical cancer and its relationship with the clinical pathological characteristic,and to assess its clinical significance. Methods:Mcl-1mRNA expression both in cervical cancer and in corresponding normal tissue was detected by reverse transcription fluorescent quantitation polymerase chain reaction method. Mcl-1 protein expression was detected by immunohistochemistry method. The correlation of Mcl-1 expression and clinicopathological features of cervical cancer was analyzed. Results:Mcl-1mRNA was higher in cervical cancer tissue when compared with corresponding normal tissue. Mcl-1 was overexpressed in cervical cancer tissue(positive rate of 53.3%) when compared with corresponding normal tissue (positive rate of 11.1%). High expression of Mcl-1 was significantly correlated with histological grade,tumor size and lymph node involvement(P < 0.05). Conclusion:Our results suggest that Mcl-1 may play an important role in cervical cancer and have potential as biomarker and therapeutic target.