Objective:To explore the differences of male infertility in different fluorine exposure populations. Methods:Villages were divided into high-fluorine-region group (n = 94) and low-fluorine-region group (n = 114). Their living situations,diet,fertility and other fluorine exposure related aspects were collected and compared between two groups. Results:Compared with low-fluorine-region group,it was significantly higher in the frequency of using coal and drinking tea,degree of dental fluorosis,and rate of infertility(P < 0.05),while significantly lower in the use of improved stoves and fluorine toothpaste in high-fluorine-region group(P < 0.05). The factors of “survey objects from high-fluorine region” and “stove unimprovement” significantly affected on male infertility in multiple Logistic regression(P < 0.05). Conclusion:Coal-burning-type fluorine exposure and the incidence rate of infertility in high-fluorine-region group was more serious than low-fluorine-region group,which suggested that long-term fluorine exposure was a risk factor of infertility,which could increase the risk of male infertility.