Objective:To investigate plasma fibrinogen levels in type 2 diabetic patients with periodontal disease,and to explore the correlation between plasma fibrinogen and periodontal diseases in type 2 diabetic patients. Methods:The study included 24 type 2 diabetic patients complicated with severe periodontal diseases,20 type 2 diabetic patients without periodontal diseases and 16 normal controls. The body mass index(BMI) was calculated,and plasma fibrinogen and blood lipids,HbA1c were determined. Results:Compared with normal control and type 2 diabetic subjects without periodontal diseases,plasma fibrinogen levels in type 2 diabetic patients with severe periodontal diseases were significantly increased. Plasma fibrinogen level in type 2 diabetic patients without periodontal diseases was significantly elevated compared with normal controls(P < 0.05). The plasma fibrinogen levels were positively correlated with HOMA-IR-HbA1c. Conclusion:Periodontal diseases may result in higher circulating fibrinogen in type 2 diabetic patients,and aggravate glucose metabolic disorder and insulin resistance.