Objective:To explore the clinical value of transient blocking of both pulmonary artery and veins on locally advanced non-small cell lung cancer(LANSCLC). Methods:Thirty cases of patients with LANSCLC using the transient blocking of both pulmonary artery and veins were selected as treatment group. Another 30 cases of patients with blocking of pulmonary artery alone were selected as control group. The operation time,bleeding amount during operation,artery-blocking time and complications after operation between the two groups were compared. Results:The artery-blocking time,operation time in treatment group was obviously shorter than those in control group. The bleeding amount during operation in treatment group was obviously less than that in control group. All of the differences had statistical significant (P < 0.01). The rate of complications after operation in treatment group (6.7%) was obviously lower than that in control group(23.3%). But there was no statistic difference between the two groups(P > 0.05). Conclusion:As a treatment method of LANSCLC,transient blocking of both pulmonary artery and veins can shorten the operation time,reduce the bleeding amount,decrease the complications after operation,and is worth to be popularized in clinical research.