Objective:To explore the value of real-time tissue elastography imaging in the diagnosis of solid nodules of thyroid. Methods:The preoperational conventional ultrasound and real-time tissue elastography imaging were carried out in 25 patients (including 35 nodules). The results were compared with pathological results. Results:The sensitivity,specificity,and accuracy of conventional ultrasound in diagnosing the malignant nodules of thyroid were 71.43%(10/14)-95.24%(20/21)-85.71%(30/35),respectively. While the sensitivity,specificity,accuracy of real-time tissue elastography imaging respectively were 64.28%(9/14)-71.43%(15/21)-68.57%(24/35). When both of the two methods were used,the sensitivity,specificity,and accuracy were 85.71%(12/14)-71.43%(15/21)-77.14%(27/35). Conclusion:Real-time tissue elastography imaging is valuable in the differential diagnosis of thyroid nodules. When applied together with conventional ultrasound,it may improve the sensitivity of diagnosing.