Objective:To investigate the expression and clinical significance of HER-2/neu and RECK in breast carcinoma tissue. Methods:A total of 76 cases of breast carcinoma tissue and 30 cases of normal breast tissue were selected and stained with SP immunohistochemical method to detect the expression of HER-2/neu and RECK,positive rate and intensity were compared among cases with different TNM stage and differentiation of breast carcinoma,correlation between HER-2/neu and RECK was analyzed in breast carcinoma tissue. Results:Positive rate and intensity of HER-2/neu were higher and RECK were lower in breast carcinoma tissue than those in normal breast tissue,which were correlative with TNM stage and differentiation of breast carcinoma,the expression of HER-2/neu was negatively correlated with RECK in breast carcinoma tissue. Conclusion:HER-2/neu was over expressed while RECK was not expressed or at a low level in breast carcinoma tissue,these might be a biological mechanism for the occurrence and progression of breast carcinoma.