Objective:To investigate the correlation between C-reactive protein(CRP) gene +1444C/T polymorphism with the risk of unstable angina pectoris(UAP) and the serum CRP level in the ethnic Sunan Han population of China. Methods:The serum level of CRP was measured by enzyme-linked immunosorbent assay and the CRP gene +1444C/T polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism between 172 patients with UAP and 230 control subjects. Results:① There was CRP gene +1444C/T polymorphism in this study population;② The serum CRP level in UAP patients (8.269/9.179 μg/ml) was significantly higher than those in control subjects (3.578/2.236 μg/ml)(P < 0.001) and multivariate logistic regression analysis showed that the serum CRP level was a risk factor of UAP;③ There was not difference in the serum CRP level in any genotypes of the CRP gene +1444C/T polymorphism between the UAP group and the control group(P > 0.05) and further grouped by gender and age. Conclusion:There was no relationship between CRP gene +1444C/T polymorphism with its serum level in the ethnic Sunan Han population of China.