Objective:To explore the relationship between platelet parameters and microangiopathy and peripheral arterial disease (PAD) in type 2 diabetes. Methods:Total 650 patients with type 2 diabetes were collected. The levels of platelet count (PLT),mean platelet volume(MPV),platelet distribution width(PDW),clinical and biochemical characteristics,microalbuminuria(MAU) and ankle brachial index(ABI) were measured. The patients were divided into MAU group and normal abuminuria group according to presence or absence of MAU. The patients were also divided into PAD group and non-PAD group according to the ABI value. The comparison of platelet parameters and biochemical indices between groups was performed. The correlation of the risk factors for MAU and PAD were analyzed. Results:The level of SBP,TC,TG,MPV and PDW in MAU group were significantly higher than those in normal abuminuria group,and the level of HDL in MAU group were lower than that in normal abuminuria group(P < 0.05). The differences in WHR,SBP and TC between PAD and non-PAD group were statistically significant(P < 0.05). However,there was no significant difference in platelet parameters between two groups(P > 0.05). Logistic multiple regression analysis shown that SBP,TC,TG and PDW were the independent risk factors of the progress of MAU. SBP,WHR and HDL were significant factors for PAD(P > 0.05). Conclusion:Monitoring the platelet parameters,especially MPV and PDW,has very important prognostic value in the early diagnosis of microangiopathy in type 2 diabetes.