The mRNA and protein expression differences of vitamin D receptor in subcutaneous and omental adipose tissues of people with different BMI
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    Abstract:

    Objective:To investigate the mRNA and protein expression differences of vitamin D receptor(VDR) in subcutaneous and omental adipose tissue of people with different BMI. Methods:Twenty people of normal BMI,35 people of overweight and 27 people of obesity were selected. The mRNA transcription levels of VDR were assayed by RT-PCR,and the VDR protein expression was measured by Western blot. Results:① In subcutaneous obesity tissue,mRNA transcription and protein expression of VDR was lower in obesity group than in the normal or overweight group(P < 0.05);② In omental adipose tissue,mRNA transcription and protein expression of VDR was highest in overweight group among 3 groups(P < 0.05). Compared with the overweight group,mRNA transcription and protein expression of VDR was lower in obesity group(P < 0.05). Conclusion:The VDR expression decreased in the obesity group,which may be one of the mechanisms of the poor clinical outcome of vitamin D intervention therapy.

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徐家蓉,张力翔,缪 珩.维生素D受体mRNA及其蛋白在不同体质指数人群皮下和大网膜脂肪组织中的表达差异[J].南京医科大学学报(自然科学版英文版),2012,(11):1575-1578.

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  • Received:July 23,2012
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