Objective:To explore the relationship between long term hemodialysis patients’ nutritional status and interdialytic weight gain(IDWG),in order to provide the guidance for preventing of the patients’ malnutrition. Methods:From 2008 August to 2007 July,123 maintenance hemodialysis patients in the end stage of chronic kidney disease of our hospital were divided into 3 groups according to IDWG%(IDWG/dry weight). Group A:IDWG%<3%;Group B:3%5%. Six serologic markers and six human body parameters were selected as nutrition indexes to evaluate the patients nutrition status. A retrospective study was adopted to investigate nutritional indexes at the three time points:before study (in the beginning),amid study (at the end of the sixth month),after study(at the end of twelfth month),and single factor analysis of variance was used to evaluate statistical significance difference among the three groups. At the same time,rank correlation analysis was also used to study the relationship between different IDWG% and all nutritional indexes. Results:Nutritional indexes were compared to each other among the three groups respectively in the beginning,in the middle and at the end of study;Single factor analysis of variance revealed no statistically significant differences(P > 0.05). Correlation analysis revealed no statistically significant correlation between different IDWG% and each nutritional index(P > 0.05). Conclusion:There was no relationship between IDWG% and the patients’ nutritional status,and no definite statistically significant correlation between IDWG and each nutritional index. The results suggest that relative low level IDWG% do not affect the patients’ long term nutritional status.